The Xoft System is FDA-cleared, CE marked and licensed in a growing number of countries for the treatment of cancer anywhere in the body. Once the tumor has been surgically removed, the Xoft System’s miniature x-ray source is inserted inside a flexible balloon-shaped applicator, which is then placed inside the tumor cavity, filled with saline, and used to deliver a single dose of radiation directly to the tumor bed. IORT with the Xoft System allows radiation oncologists and surgeons to work together to deliver a full course of radiation treatment in one day, at the time of surgery, while the patient is under anesthesia. For the treatment of certain types of brain tumors, IORT with the Xoft System may allow appropriately selected patients to potentially replace weeks of post-operative external beam radiation therapy (EBRT) with a single fraction of radiation. Xoft brain IORT is a promising treatment option that may offer better outcomes for patients, with minimal side effects, compared to traditional radiation therapy. Treatment for brain tumors typically involves surgical removal, followed by radiation therapy or chemotherapy. 1 Glioblastoma (GBM) is the most common and aggressive type of malignant primary brain tumor, with a median survival of 10-12 months. Worldwide, almost 297,000 cases of brain and nervous system tumors are diagnosed per year.
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